GLP-1s are building a reputation as "wonder drugs." First characterized for their ability to improve insulin release and ...

Project Leader: Victor Thannickal, M.D. Idiopathic pulmonary fibrosis (IPF) is chronic, progressive lung disorder with high mortality, and limited therapeutic options. Studies performed during Cycle I ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

CGTE researchers Dr. Stelios Andreadis, center director, and Dr. Kirk Personius are lead co-authors of a paper in the October 24th edition of Nature Communications. This study describes experiments ...

Gram-stained section of a macrophage with ingested S epidermidis bacteria, seen as purple granules within its cytoplasm. In this stain, the nucleus appears pale, with a reddish nucleolus. It is ...

Below, we’ve brought together the month’s themes in our new Trends Outside the Headlines, trends & insights report, collecting together and assessing the signals that matter for life sciences ...

Epigenetics, the dynamic regulation of genetic expression, involves complex molecular mechanisms. While the process of gene silencing by methylating the H3K27 position in histones is understood, not ...