Regenerative medicines are headed for people with Parkinson’s disease or severe heart failure — but researchers are concerned about minimal clinical-trial data.

A mature cell of one type can be turned into a mature cell of another type without the cell having to pass through an earlier stage of development. This is called direct reprogramming, a reliable but ...

A pioneering clinical trial is exploring whether lab-engineered stem cells can restore dopamine production in people with Parkinson’s disease.

A team led by researchers has discovered that a group of cells located in the skin and other areas of the body, called neural crest stem cells, are the source of reprogrammed neurons found by other ...

A groundbreaking clinical trial is testing whether specially engineered stem cells can help the brain restore its own ...

After treatment, the mice’s memories were essentially shunted back into a younger state. The researchers found that reprogrammed engrams displayed molecular behavior of more youthful cells. Using a ...

Parvalbumin (PV) interneurons act as the brain’s rhythm keepers. By regulating local circuit activity and maintaining excitation–inhibition balance, they help stabilize cortical network function. When ...

Using participant skin cells reprogrammed into neurons, Weill Cornell Medicine researchers have identified genetic signatures associated with HIV infection that may contribute to the cognitive ...

Pasca Lab specializes in growing three-dimensional organoid models from reprogrammed stem cells, which capture molecular changes during fetal brain-like development. Because the human brain cannot be ...

In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the “recipe” for the transformation. Researchers at Lund University have now created ...