Nature

Retroviral vector integration in post-transplant hematopoiesis in mice conditioned with either submyeloablative or ablative irradiation

A recent clinical trial in two adult X-CGD patients incorporated partially ablative busulfan conditioning before the infusion of autologous CD34+ cells transduced with the SF71gp91 phox γ-retroviral ...
Nature

Rapid detection of retroviral vector integration sites in colony-forming human peripheral blood progenitor cells using PCR with arbitrary primers

We have developed a highly sensitive polymerase chain reaction (PCR)-based technique termed two-step PCR, which uses arbitrary primers to identify proviral integration sites in retrovirally marked ...